I have a similar setup and decision point on a 2020 Minnie Winnie 22r (with 2019 E-350 chassis). This RV also came with the Hankook 225/75R/16 tires, and are approaching the 5 year age (manufacturing date: Oct/1

. These tires have 26K miles, and are starting to show a little uneven wear. It's also worth noting that I've never had them rotated. The other factor in my decision, is an upcoming cross country adventure of over 5000 miles through various terrains and temperature conditions.
Two different RV tire shops have recommended the Michelin Agilis Cross Climate tires, however one was suggesting the Goodyear Wrangler Workhorse HT as an alternative - especially for extended gravel/dirt road travel. I've also got the Toyo Open Country HT, and Kuhmo Krugen HT51 on the list.
For me, I've had a less than positive experience with Michelin tires (Premiere LTX All Season) on our Subaru Outback. They gave a nice, quiet, almost "spongy" ride, but reduced the handling on turns for that vehicle. After 20K miles they were wearing unevenly on the edges - even though I rotated every 6000 miles. They were replaced under warranty, and I went back to the original Bridgestone tires that come with Subaru Outbacks. It's much better with the Bridgestone tire. That said, I understand that a Minnie Winnie is quite different than an Outback...
It may be too soon for feedback, but was wondering how the Agilis has been doing on your rig?