If you search the forums, you'll find comments from owners who have put a sleep number bed into their 24D. Because head of the bed folds when the murphy bed is up, they have to deflate the sleep number bed before raising the bed and reinflate when lowering the bed.
We have a sleep number at home - and the stock mattress is clearly not in the same comfort class. We have talked about getting a mattress topper instead, but haven't felt the issue serious enough to do that (so far).
If you're camping full-time in the D, then it might make sense. But if it's for vacations and long weekends, may not be worth the hassle of doing the extra deflate/inflate - plus working out where to house the pump and work out the wiring.