Using the info I could find based on your Profile I took a guess that you have a 2001 Adventurer on a F53 chassis. I hope that's correct. If not please let me know so I can fix your title.
When asking for any help we always need to know the year, model and floor plan designator to know exactly what specific RV you are asking about.
Most of us put this info in our Signature in our Profile. That way we don't have to remember to add that info to every post. I'll post instructions below on how to modify your Signature.
As, to dash Air/Heat that is usually a function of various vacuum operated mixing valves. Also, many times engine designers setup the A/C compressor clutch to disengage under heavy load or acceleration. This stops the compressor from sapping your engines power but it also cuts your A/C cooling. On the other hand, engine vacuum increases and decreases based on how much air is flowing through the intact manifold into the engine. So, this would result in changes in those vacuum mixing valves as you accelerate or let off the gas.
Figuring out the issue takes more info about when this happens and what seems to be happening at the time you lose cooling. Not easy for us to do over the internet.
Sometimes a visit to an Auto Air Conditioning shop can sort these issues out quickly - but keep in mind that the mainly plastic parts that make up this system get aged and brittle over 20+ years of use.
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2017 Winnebago Adventurer 37F
2016 Lincoln MKX Toad
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