A few things we have found helpful...
Try if at all possible to avoid schedules! Trying to be somewhere by X date can create stress and a situation when you travel in less than ideal conditions. If you do have to be somewhere at a particular date, give yourself plenty of slack time.
In the lower 48 states, we plan on travel days of about 350-400 miles assuming that most of that is Interstate travel. For non-Interstate roads, try to plan for 250-300 miles a day. In Alaska and in Canada (on the way to Alaska), no more than 250 miles a day worked out well.
We usually get underway about 8:30ish and like to put the jacks down about 3ish.
After three or four days of travel in a row, we are ready to spend a couple of days for a break.
I like TL's Campground Navigator (program for the PC) when planning stops - I figure out where 300-400 miles is towards our destination and look for nice CGs on our route in that circle. If they are the typical Interstate overnight CGs, I don't bother to call ahead. Better call ahead though for resort-type CGs. We have been to a couple of nice CGs handy to the Interstate where they book up on the weekends. We found that if the CG has a pool and activities for families, make reservations for a weekend stay in the summer.
You will have a blast
Just be flexible and not in a hurry.
In fact, I'm getting excited about getting our 'beast' ready for the road - we're rarin' to go again!